A recent study by Quadrilatero and Hoffman-Goetz sought to determine the impact of NAC infusion on the development of apoptosis in rats that were infused with either saline or NAC and ran to exhaustion
But glutathione doesn't just defend
Moreover, a variety of furanocoumarins, including 8-methoxypsoralen and other furanocoumarins, can cause mechanism-based inactivation of CYP 450 ( 2.3 Metabolic Activation of Epoxy Diterpenoids-Induced Hepatotoxicity Belonging to the Celastraceae family, Tripterygium wilfordii Hook has been used for numerous centuries in traditional Chinese medicines for treatment of rheumatoid arthritis ( T
16, Sonthalia, Sidharth, et al
Nat Metab 3 , 297298 (2021)
The evidence is preliminary but promising