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CrossRef Social Determinants of Health in Metabolic DysfunctionAssociated Steatotic Liver Disease and AllCause/CauseSpecific Mortality Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, Rohit Loomba, Aijaz Ahmed Alimentary Pharmacology & Therapeutics .2026

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Collectively, these metabolites form an integrated, synergistic network that enhances receptor expression, increases ligand availability, and converges on common neuroendocrine circuits, including vagal afferents and hypothalamic pathways, thereby exerting a coordinated regulatory effect on the gutbrain axis (126)

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