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Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by tumor necrosis factor

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Multiple studies have shown that GPER activation may improve insulin resistance by regulating insulin receptor substrates (IRSs) and the PI3K signaling pathway, thereby amplifying the biological effects of insulin [4, 174]

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KPV is the C-terminal tripeptide lysine-proline-valine, a low-molecular-weight sequence frequently used in comparative small-peptide analytical work