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Important safety note: Because retatrutide is unlicensed in the UK, there is no MHRA-approved Summary of Product Characteristics or monitoring recommendations for routine clinical use, and there is no regulated supply chain

Overall, the role of the gut-liver axis in treating metabolic dysfunction-associated fatty liver disease by GLP-1RAs is essential

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For those with established atherosclerosis, the focus would be on managing the existing condition and preventing further progression [31]

Zhou J, Livak MF, Bernier M, Muller DC, Carlson OD, Elahi D, Maudsley S, Egan JM (2007) Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets

A review of MASLD-related hepatocellular carcinoma: progress in pathogenesis, early detection, and therapeutic interventions