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reported that MTX caused weight loss due to malabsorption and enterocolitis in rats (Reference Fox, Kripke and De Paula37,Reference Jahovic, Cevik and Sehirli38)

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Celebi Sozener Z, Ozdel Ozturk B, Cerci P, Turk M, Gorgulu Akin B, Akdis M, et al

This has led to a proliferation of private clinics and practitioners offering so-called booster shots of B12 as a pick-me-up to help decrease fatigue, improve mood, motivation, and provide a feeling of being refreshed even in those without a diagnosed deficiency, also targeting vegans and vegetarians as a cohort at risk of B12 deficiency

aimed to explore the role, if any, of ethnicity and other potential confounding factors in the association of GGT with incident T2D, by prospectively evaluating a large sample of 6928 adults of Hispanic/Latino background who were free of T2D or hepatitis virus and did not drink excess alcohol at study entry, over a six-year follow-up [39]