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Recent studies have revealed that heightened autophagy and lysosomal activity could contribute to the promotion of ferroptosis by facilitating iron accumulation or lipid peroxidation (Zhou et al., 2020)

The first step (for all OA patients) is following an anti-inflammatory diet (mainly the MD, rich in -3 PUFAs, fruits, vegetables, and whole grains), combined with weight loss of 510% (for those with a BMI 25) and low-impact exercises (such as swimming) for 3 months

Early symptoms include nausea, vomiting, and abdominal pain, but severe cases progress to liver failure and death if not treated promptly

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Li, P., Yang, R