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The absence of a significant eGFR change in our cohort likely reflects lower baseline kidney risk and the shorter observation period: baseline eGFR was ~ 76 ml/min/1.73 m 2 versus ~ 47 ml/min/1.73 m 2 in FLOW, and our follow-up was 1 or 2 years versus a median 3.4 years in FLOW, which may be insufficient to detect meaningful eGFR differences in earlier-stage T2D

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