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ZA is supported by National Health and Medical Research Council ideas grant application ID 2012582

doi: 10.1073/pnas.1212806109 62 TroutKKBasel-BrownLRickelsMRSchuttaMHPetrovaMFreemanEWet al

The expiry date of patent A = effective filing date of patent C (20 April 1998) + 20 years + PTA adjustments (100 days)

Despite reduced food intake, patients must ensure adequate micronutrient consumption, including: Calcium and vitamin D for bone health Iron and B vitamins for energy metabolism Adequate fibre for digestive health Regular monitoring by healthcare professionals is essential

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Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans