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Moreover, the narrow affinity range observed across targets implies a balanced mechanism of action, potentially minimizing systemic side effects common in traditional chemotherapeutics

Minoxidil's mechanism is similar (vasodilation), but it's non-specific

The discount rate applied to pharmaceutical assets typically ranges from 8% to 15%, reflecting the cost of capital and the binary nature of clinical risk

In one embodiment of the present invention the ratio of organic modifier to water, on a weight percent basis, is from 1:99 to 99:1, such as 1:99 to 80:20, 20:80 to 80:20, 30:70 to 70:30, 35:50 to 50:35, or 40:50 to 50:40

This allows cells to survive for longer, which helps to delay the onset of age-related macular degeneration, cataracts, and other retinal disorders

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