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It simply allows your body more time to adjust, which often improves overall adherence and compliance with the full protocol

Although initial findings suggest that GLP-1Ra leads to a slight reduction in bone mineral density and promotes bone remodeling, favoring resorption similar to calorie restriction effects, further research is needed to explore the effects of GLP-1Ra on bone metabolism and fracture-related outcomes, as well as dual- and triple-receptor agonists of GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon in PwO

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Participants who titrated from the lowest starting dose (2mg) generally achieved slightly better outcomes at the 12mg target

doi:10.1530/JOE-10-0419 47

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