NAD+ levels naturally decline with age, a phenomenon observed across multiple tissues and species
The Negatives: What the Trials Showed Across programs like STEP, SURMOUNT, and SELECT, side effects were largely gastrointestinal: Nausea, vomiting, constipation, diarrhea
Be wary of knockoff or non-prescription versions of these medications that have not been thoroughly tested for safety or efficacy
JAMA Internal Medicine (2026)
1 Psychosocial and metabolic stress , the physiological burden of adapting to a new medication and a changing body composition, can itself be a shedding trigger
Stopping at six months leaves significant weight loss potential unrealized and insufficient time for metabolic and behavioral adaptation