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Indication-specific advantages: Glucagon co-agonists such as survodutide, mazdutide, and retatrutide may have superior hepatic effects in MASH and MASLD because glucagon acts directly on liver lipid metabolism

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When diarrhea is most likely to occur Diarrhea tends to follow a predictable pattern on GLP1 medications: After starting treatment : The first few weeks on a new medication are the most common time for GI symptoms

Management of AEs GI AEs typically occur during initiation and uptitration, appearing as transient, mild-to-moderate symptoms

Implants Implantable SC implants and osmotic pumps represent advanced technologies for sustained drug delivery, leveraging distinct mechanisms to achieve long-term therapeutic efficacy

Exenatide The first class of GLP-1s was approved