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6 The Many Complications of Chronic Kidney Disease CKD is associated with a wide range of significant health complications, including 64 : Cardiovascular Disease Cardiovascular disease, particularly advanced cardiovascular disease, is associated with a significantly elevated risk of various cardiovascular problems, such as hypertension (high blood pressure), arterial calcification (calcium buildup in the arteries), heart failure, valvular disease (damaged heart valves), and atherosclerosis
NADPH oxidase Nox4, a putative therapeutic target in osteoarthritis
Surgery 149 , 654661 (2011)
There are several known mechanisms that explain its neuro-protective effects: It plays a pivotal role in combating oxidative stress, reducing inflammation, and promoting mitochondrial function, and it is a precursor to glutathione
Wijesekara et al
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