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Immediate endocrinology referral is warranted for patients with very low testosterone levels accompanied by normal or low LH/FSH, elevated prolactin, or symptoms such as headaches or visual disturbances that might suggest pituitary dysfunction

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17 estradiol has been shown to suppress hepatic glucose production and gluconeogenesis through inhibition of the transcription factor Foxo1via activation of estrogen receptor-phosphoinositide 3-kinase-Akt signaling (72)

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Specifically, edges between intersection nodes, pathways shared by both DM2 and AD, were assigned the highest weight (3), as these represent core molecular mechanisms directly contributing to both diseases