Pooling across the field, a 2025 meta-analysis of seven randomized controlled trials, covering 456 participants, reported a standardized mean difference of -0.72 for wrinkle reduction, though the analysis noted high heterogeneity between studies and that roughly 40% of trials had industry funding both factors that warrant caution in interpreting the pooled effect size
Whether you are focused on skin health, energy, or longevity, we believe that informed choices lead to better outcomes
Other Options to Ensure Enough Vitamin B If you are not a big fan of needles or want to try other methods first, you can always try a dietary supplement
Nine out of ten times, people will do the first two things, but you can use the topical product too so levels can be enhanced faster
Seek immediate medical attention if you experience chest pain, rapid or abnormal heartbeat, or difficulty breathing
Mol Med (2011) 17:104555