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Contact your healthcare provider immediately if you experience: Severe, persistent diarrhea lasting more than 48 hours or accompanied by signs of dehydration (dizziness, decreased urination, extreme thirst, dry mouth) Severe abdominal pain , particularly if constant, worsening, or localized to the upper abdomen and radiating to the back Persistent vomiting that prevents you from keeping down fluids or medications Blood in your stool or black, tarry stools Signs of pancreatitis , including severe upper abdominal pain, nausea, vomiting, and fever Symptoms of gallbladder disease , such as right upper abdominal pain, fever, or jaundice (yellowing of skin or eyes) Stop taking Zepbound immediately and seek urgent medical care if you suspect pancreatitis

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Dehydration can make GLP-1 side effects like nausea and constipation worse (this happened to me), and it can really zap your energy, too

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10.1186/s40001-022-00982-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 463.Ke, J

Post-hoc analysis of the SURMOUNT trial data found that tirzepatide relative to placebo was not associated with increased risk of depressive symptoms