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Inflammatory cytokines contribute to brain endothelial cell activation and downregulation of tight junction proteins, such as zonula occludens-1 and claudin-5, resulting in bloodbrain barrier dysfunction [55]

10 (1), e00014

Here, we showed for the first time that not only inhibition of FOXO4 itself, but more specifically, blocking the FOXO4-p53 binding by cell-penetrating peptides could effectively eliminate senescent cells and therapy-resistant cancer cells

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( 10.1016/S2213-8587(2030043-7) [DOI] [PubMed] [Google Scholar] 62.Cole AR, Astell A, Green C, Sutherland C