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Finally, the monoclonal antibody MRA003US is currently in a phase I trial (NCT00046774) and no results have been released to date

Int Immunol (2014) 26:23342

By blocking opioid receptors on the POMC neurons, feedback inhibition is prevented further increasing POMC activity

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Our model simulations are reflective of the hepatic GSH environment, agreeing with the supra-pharmacological concentrations of doxorubicin required to illicit comparable GSH depletion in the liver 39

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