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Steroid hydroxylation by basidiomycete peroxygenases: a combined experimental and computational study

PMC 7613997

Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)

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NNMT inhibition could have effects on methylation balance and other metabolic pathways that have not been evaluated in people