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Levels of glutathione may decline over time and can be influenced by factors such as age, lifestyle, diet, and environmental exposure , leading to increased interest in supplemental forms
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The transcription factor p53 also plays a dual role in melanocyte defense by upregulating tyrosinase, a key enzyme in melanogenesis, and enhancing the antioxidant response via the Nrf2 pathway 17 , but also it can stop the melanocyte cell cycle, even leading to apoptosis 79
Lactate produced by glycolysis increases the lactylation level of PKM2 protein, which inhibits its tetramer-to-dimer transition, reducing nuclear distribution and enhancing its pyruvate kinase activity in the cytoplasm (48)
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Following exposure to cigarette smoke, there was an observed increase in both iron and ferritin concentrations within rat lungs [102]
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