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Alcohol depletes glutathione: Chronic alcohol consumption severely reduces hepatic glutathione through increased oxidative stress during ethanol metabolism [6][35]

Conclusions : It appears that 500 M and pathophysiological concentrations (800 M) of UA induce antioxidant cell response in J744A.1 macrophages proved by the indicative elevation GCL, GPx1, GR, and GS transcription

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