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Employers that are unwilling or unable to offer health plan coverage of GLP-1 drugs for weight management may consider offering consumer-driven health plans and tax-advantaged accounts, such as health savings accounts (HSAs) or flexible spending accounts (FSAs)

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Patients exploring options such as Mounjaro or Zepbound as part of a broader metabolic health conversation with their provider may find it helpful to compare how titration philosophies differ across compounds, since not every option follows the same dosing structure

Specifically, mutagenesis of ECD, ECL1 and ECL3 individually increased the basal activity of GCGR, which could result from the interruption of intramolecular interactions between the ECD and ECL1/3 that otherwise stabilize the receptor in an inactive state

Finucane et al