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Participants on Zepbound also lost significant amounts of weight: about 18% of their body weight, on average, in the first trial and about 20% in the second, compared with 1.6% and 2.3%, respectively, for those on placebo

The REWIND trial's cognitive substudy with dulaglutide and smaller trials of liraglutide in Alzheimer's disease have shown modest or inconsistent effects

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