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For anyone expecting to escalate beyond 5 mg, a higher concentration is generally more practical

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To investigate the direct effect of GLP-1R agonists on sperm motility, cauda epididymis samples were collected from 8-week-old male C57BL/6 J mice (eight mice per group)

In clinical trials, these effects usually eased as people settled on a stable dose

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Results Subject Disposition and Characteristics In the food-effect trial, 116 subjects were screened, 78 were enrolled, randomised and exposed, and 77 completed the trial (Supplementary Fig