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[1] While this is usually not clinically significant for most medications, it's worth noting, particularly when initiating treatment

Diabetes Care 40 , 6976 (2017)

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[8] Oxidation of dimethyl sulfoxide produces the sulfone, both under laboratory conditions and metabolically

Inzucchi reports honorarium for consulting and/or clinical trial committee work from AstraZeneca, Boehringer Ingelheim, Novo Nordisk, Merck, Pfizer, and Bayer