308 Overactivation of NMDARs by A leads to abnormal calcium influx, triggering a cascade of downstream signaling events, resulting in dendritic spine loss, reduced distribution of NMDARs on neuronal membranes, impaired synaptic plasticity, and ultimately, cognitive decline
In fact, a difference in experimental conditions as well as cell-type specificity of plasticity mechanisms and heterogeneity of recorded subpopulations of interneurons could have contributed to discrepancies between the findings of the above studies, e.g., whether CA1 inhibitory neurons express predominantly LTD (McMahon and Kauer, 1997) or also LTP (Taube and Schwartzkroin, 1987
Given the impressive efficacy of tirzepatide in treating obesity and overweight and treating and even preventing diabetes, its use may still be considered despite a lack of evidence in this specific population
This magnitude cannot be explained by GLP-1R engagement alone and supports the adipose GIPR mechanism
It has been shown to reduce the risk of major adverse cardiovascular events, including heart attack and stroke, in people with type 2 diabetes who have a high risk of cardiovascular disease
Lipids 48 , 319332, doi: 10.1007/s11745-013-3774-6 (2013)
