The overall matched cohorts contained 47,199 patients per arm and were closely balanced for age at the index event (59.4 versus 59.9 years), female representation (62.8% versus 61.3%), baseline BMI (35.6 versus 35.3 kg/m 2 ), and baseline documented type 2 diabetes prevalence (25.8% versus 26.0%) (Table 2)
Preclinical studies across diverse neurodegenerative conditions consistently demonstrate neuroprotective effects of GLP-1RAs, including reduced protein aggregation, enhanced autophagy, improved mitochondrial function, suppression of neuroinflammation, and preservation of synaptic integrity
It is intended strictly for scientific research and is not formulated for human or veterinary use, therapeutic applications, or dietary supplementation
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Additionally, GLP-2s glucose-dependent action minimizes the risk of hypoglycemia, a common side effect of many diabetes medications
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