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For general wellness and maintenance, once or twice a month is typically sufficient, as nutrient levels remain elevated for two to three weeks following a session

6. Duca F et al

3.3 Changes in serum cobalamin by supplementation route and dosage Across 35 comparisons, the mean percentage increase in serum cobalamin following supplementation was approximately 293%, confirming the overall effectiveness of vitamin B12 interventions (Supplementary Table S4)

The overall dosage is between 3-7 times

After 6 weeks, I went back to the recommended intake by my GP, and noticed the decrease in my overall sense of well being

The cost of labs may also vary if you are using insurance or paying out-of-pocket