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Participants had been recently hospitalised and had poor endurance (the mean 6-min walk distance at baseline was only 220 m) [141]
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Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)
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