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However C8 itself may also increase PGC-1 expression through its interaction with another G protein-coupled receptor GPR40 (also known as free fatty acid receptor 1, FFAR-1), known to be activated by MCFAs [although C8 shows lower affinity compared to C10 (93)]
The concern is dosing accuracy, not safety
That framing matters because supporting your bodys own GLP-1 production is not the same as taking a GLP-1 receptor agonist medication
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Mechanism of GLP1R Signaling As previously mentioned, GLP1R primarily exerts its biological functions by binding to its ligand GLP-1 and its analogs
Lancet, 1985
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