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Therefore, the acidic residues of p53 TAD appear to have no significant impact on its interaction with the FOXO4 FHD, as these residues primarily contribute to DNA selectivity rather than binding to the FOXO4 FHD

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It is notable for its ability to traverse the blood-brain barrier, enabling systemic and central nervous system effects ( 1, 8 )

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Gastrointestinal Effects The most common side effects involve the digestive system, occurring in roughly 28% of participants at the 12mg dose