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Glucagon naturally increases energy expenditure and promotes fat breakdown
Heterologous expression in vitro unveiled its constitutive activity capable to raise intracellular cAMP levels through Gs (321) and lead to the secretion of GLP-1 and PYY (89)
Slow responses during critical moments, such as dosing errors or medication shortages, create real frustration
Funding This work was supported by the Natural Science Foundation of Shanghai (22ZR1410900)
*Archives of pharmacal research* , 30 (7), 834-839.
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