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46,47,48 In 2005, the discovery of pseudouridine () modification addressed the immunogenicity issue of in vitro-synthesized mRNA, 49 leading to the initiation of the first human trial of an mRNA vaccine against melanoma in 2008

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Each macronutrient category was examined with respect to its impact on outcomes such as hepatic encephalopathy, sarcopenia, hospitalization risk, and survival

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