The recently developed receptor agonists for glucagon-like peptide-1 (GLP-1RAs), stimulate insulin secretion and reduce glycated hemoglobin levels without having side effects such as weight gain and hypoglycemia
GLP-1 drugs (exenatide, liraglutide etc), as well as GIP/GLP-1 hybrid peptides (tirzepatide), are clinically approved for diabetes and/or obesity, with GLP-2 based drugs (teduglutide) approved for the treatment of short bowel syndrome
*P.B.s Medicare Part D plan for medications wont cover Mounjaro due to a federal law passed in 2003 that prohibited Medicare from covering weight management medications because of supposed dangerous side effects
These medications may have both positive and negative effects on the gastrointestinal tract
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Furthermore, chronic GIP-receptor agonism can lead to desensitization and eventual loss of GIP receptor activity, which then mimics antagonism