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GLP-1 (Glucagon-Like Peptide-1) plays a key role in hunger control, digestion, and metabolic efficiency

For example, recently it was reported that a rhubarb extract, Rhein, increasing the intestinal population of Bacteroidetes, mediates an increase in ileal GLP-1 producing cells, peripheral GLP-1(7-36) NH2 levels and improved glucose tolerance in diabetic db/db mice (395)

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6 Moreover, GIPR signaling blocks emesis and attenuates other negative side effects of GLP-1 receptor (GLP-1R) activation

doi: 10.1186/s12933-020-01148-8, 18 ChristensenS.RobinsonK.ThomasS.WilliamsD