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This is important because GLP-1 drugs were originally designed to have a long half-life in blood to maximise their efficacy in the treatment of diabetes which prevents them from entering the brain (Hlscher)
For example, a 2025 study in the Journal of the American Medical Association (JAMA) found people taking Ozempic were about 1.8 times as likely to experience vision loss from NAION, than those prescribed other diabetes medications
If people stop medication, many are likely to need ongoing nutritional and behavioural support, and health services should anticipate that cardiometabolic benefits may lessen as weight is regained, Spreckley said, adding that this highlights the need for further research into effective, scalable strategies for long-term weight maintenance alongside pharmacotherapy. GLP-1 medications have become widely used in recent years, and more than 15 million Americans are now losing weight with the drugs
BPC-157 is now regarded mostly as a research molecule rather than a clinical treatment
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