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Random-effects models were used for meta-analysis, with heterogeneity, sensitivity analysis, meta-regression, and publication bias assessments conducted

Because the two pathways are separate but converge on the same GH-secretory machinery, activating both together has been shown in preclinical models to produce greater GH pulse amplitude than either alone

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Characterized by an autoimmune attack against the thyroid gland, Hashimotos leads to a gradual decline in thyroid function, culminating in hypothyroidism