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Data from the STEP (weight loss) and SUSTAIN (diabetes) trials shows the most common semaglutide side effects are gastrointestinal

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

Current guidelines do not recommend combination therapy with GLP-1 RAs and DPP-4 inhibitors, and the ADA/EASD consensus report specifically recommends discontinuation of DPP-4 inhibitors when initiating GLP-1 RA therapy

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Some patients will see enough weight loss after the initial stage that continued treatment is not needed