glp 1 negative effects reddit Users Are Reporting GLP-1 Side Not Captured in Clinical Trials Does GLP-1 Cause Muscle Pain?

Additionally, the FDA recommends that these medications not be taken during pregnancy and be discontinued at least two months prior to pregnancy, because studies in rats, rabbits, and monkeys demonstrated that animals treated with these medications had higher rates of miscarriage, were born smaller, and were more likely to have birth defects

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The STEP-1 Trial evaluated semaglutide plus lifestyle intervention vs

The clinical investigators specifically noted that "gastrointestinal adverse events were partially mitigated by the use of a lower starting dose." Starting at 1 mg, which is what the Phase 3 TRIUMPH trials use, provides even more tolerability protection