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Compared to an average loss of just 0.880.08% of baseline body weight in the placebo group by 104 weeks post-randomization, patients in the semaglutide arm had lost an average of 9.390.09%

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With the exception of interactions of Glu1 and Asp3 with polar residues deep in the bundle, the first 9 residues of exendin-P5 do not form stable interactions with the TMD

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