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There is no human trial of this exact combination, so the evidence here is built from studies on the individual components, most of it preclinical
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While the total amount of weight you can lose on semaglutide is pretty significant studies show people can lose an average of 15-18.7% of their weight, depending on their dose, after a little more than a year it doesnt all happen at once
Extending the timeline to observable results
Furthermore, they increase crypt cell proliferation and reduce cell apoptosis, reduce intestinal permeability and dysbiosis and promote nutrient absorption, all of which may have an impact on conditions such as inflammatory bowel disease (IBD) [3]