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Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptor

Because it works with your own feedback loops, it avoids the shutdown effect of synthetic HGH

The closest human evidence in its drug class is Athira Pharma's fosgonimeton (ATH-1017), a structurally distinct molecule in the same HGF/c-Met program whose Phase 2/3 LIFT-AD Alzheimer's trial failed its primary endpoint in September 2024 (GST 0.08, P=.70)

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