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Decotiis Explains Overcoming barriers Oral delivery of GLP-1 therapies is advancing through two complementary strategies that aim to overcome low gastric stability and poor epithelial uptake

Merzon E, Green I, Shpigelman M et al

The cardiovascular benefits of GLP-1-RAs arise primarily through indirect systemic mechanisms, with limited evidence supporting direct effects on cardiomyocytes ( Figure 1 )

The combination of GLP-1(736) and (936) was slightly more inhibitory than GLP-1(936) alone when tested at 1 mmol/l glucose but did not produce an additional inhibition at 10 mmol/l glucose

Ferroptosis is a regulated cell death (RCD) mechanism characterized by iron-dependent lethal lipid peroxide accumulation [9]

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