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The patient ends up in a worse body composition position than before treatment began

Effect of probiotics on vaginal Ureaplasma parvum in women suffering from unexplained infertility

Theoretical concerns regarding pancreatitis and thyroid tumors, observed in animal studies with GLP-1 receptor agonists, warrant ongoing surveillance in human populations

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This does not mean the exposure was risk-free, but it means outcomes are often good despite imperfect circumstances