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Scientists from the WHO recently wrote: "The approval of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for the treatment of obesity creates potential for a transformation of the whole health system that could halt and reverse the global obesity pandemic through prevention and effective integrated management." Growing crisis South Africa is grappling with dual diabetes and obesity epidemics, on top of the HIV and TB epidemics, but is not responding effectively, resulting in high obesity and diabetes-related deaths

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The workflow of bioinformatic analysis is shown in Fig

GIP Receptor Limb GIPR engagement is the distinguishing feature separating dual agonists such as tirzepatide from single GLP-1R agonists