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found that Receptor-interacting protein 2 (RIP2) can regulate cartilage degradation and oxidative stress in IL-1 -treated chondrocytes by regulating TRAF3 expression and p38-MAPK pathway activation (Pan et al., 2021)

Santillo M, Migliaro A, Mondola P, Laezza C, Damiano S, Stingo S, et al

Selenium contributes to the normal function of the immune system

doi: 10.1128/JVI.75.22.11178-11184.2001

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It is interesting to note that CP17, which was originally designed to target the lipid-binding pocket within VP1, binds very specifically at a completely separate site and shows no evidence of binding within the targeted pocket