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Relationship to the GH-IGF-1 Axis Because this fragment does not appear to stimulate IGF-1 production in laboratory models, it provides researchers with a tool to study the IGF-1-independent aspects of GH signalling in metabolic biology

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In particular, vitamin B12 deficiency may play a role in hair loss

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Despite this relatively short half-life in circulation, the downstream metabolic effects persist for significantly longer due to the sustained activation of lipolytic enzymes and metabolic pathways initiated by the peptide