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For MP2RAGE T1w images of the PIPD, TMS and MRgFUS dataset, the brain was first extracted from the uniform T1-weighted image using Advanced Normalized Tools (ANTs) 110

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Oxidation: Certain amino acids in the peptide chain are susceptible to damage from oxygen

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TFAM binds to mtDNA and forms a nuclear-like structure, thereby protecting mtDNA from the adverse effects of A toxicity and oxidative stress, inhibiting the vicious cycle of neuronal mitochondrial dysfunction, and thus improving the pathophysiology of Alzheimers disease (Oka et al., 2016)

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