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PRRT with octreotide aims to selectively irradiate somatostatin receptor 2 (SSTR2)-expressing neuroendocrine tumor cells and the surrounding blood vessels to inhibit the angiogenetic response during treatment 67

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The first step requires the expression of the PKC domain of interest as a fusion protein with the GST moiety

It reduces the production of melanin, the pigment responsible for skin colour, leading to lighter skin

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Therefore, this review provides a comprehensive synthesis of the mechanistic insights, therapeutic potential, and associated challenges of targeting ferroptosis in PDAC