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Lower blood sugar through enhanced insulin secretion

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Morning dosing synchronises peptide availability with the natural UV-independent melanogenesis window, while evening dosing forces receptor activation against falling cortisol and rising melatonin, which suppresses melanocortin signalling

doi:10.1016/S0891-5849(97)00286-4 Lang CA, Mills BJ, Lang HL, Liu MC, Usui WM, Richie J, et al

Data are either representative of 3 experiments or mean+s.e.m., n = 3